韩松 副教授

职称职务：副教授，硕士生导师

学科专业：病理生理学

研究方向：神经免疫

实验室位置：澳门新葡游戏网1号楼4楼

Email：hansong@whu.edu.cn

学习经历

1999.09－2003.7 武汉大学生命科学学院，生物技术专业，本科

2003.09－2008.7 武汉大学生命科学学院微生物专业，博士

主要工作经历与任职

2008.09~2011.03 澳门新葡游戏网，博士后

2011.04~2016.12 澳门新葡游戏网，讲师

2017.01~至今  澳门新葡游戏网，副教授

目前主要科学研究领域和兴趣

从事神经系统自身免疫疾病的发病机制和治疗研究，包括神经免疫疾病发病机制研究，靶向钾离子通道的生物活性肽设计筛选及其作用机制，及药用活性肽治疗神经免疫疾病的临床前基础研究。先后主持国家级及省部级科研项目4项，公开发表SCI收录学术论文10余篇。

主要学术兼职

湖北省病理生理学会理事

教学情况

承担床临医学相关专业本科生、留学生和研究生的病理生理学相关理论和实验课程的教学工作，包括《病理生理学》、《损伤与反应》、《机能学实验二》、《临床病理生理学》等课程的教学，公开发表教学论文1篇。

获奖及荣誉

近五年主要代表性论文

1. Inhibition of DPP4 enhances inhibitory synaptic transmission through activating the GLP-1/GLP-1R signaling pathway in a rat model of febrile seizures. Zhang Y, Liu Y, Xu J, Sun Q, Yu F, Cheng J, Peng B, Liu W, Xiao Z, Yin J, Han S*, He X. Biochem. Pharmacol. 2018 Oct;156:78-85.

2. A Kv1.3 channel-specific blocker alleviates neurological impairment through inhibiting T-cell activation in experimental autoimmune encephalomyelitis. Yuan XL, Zhao YP, Huang J, Liu JC, Mao WQ, Yin J, Peng BW, Liu WH, Han S*, He XH*. CNS Neurosci Ther. 2018, doi: 10.1111/cns.12848. (Co-correspongding author)

3. Kv1.3 channel blocker (ImKTx88) maintains blood-brain barrier in experimental autoimmune encephalomyelitis. Huang J.#, Han S.#, Sun Q., Zhao Y., Liu J., Yuan X., Mao W., Peng B., Liu W., Yin J., He X., Cell Biosci. 2017, 7:31.

4. Zhongcheng Wang, Yusong Zhang, Jian Fang, Fang Yu, Duanhe Heng, Yuanteng Fan, Jian Xu, Biwen Peng, Wanhong Liu, Song Han*, Xiaohua He*, Decreased methylation level of H3K27me3 increases seizure susceptibility. Mol Neurobiol. 2016, DOI 10.1007/s12035-016-0197-4. (Co-correspongding author)

5. Zongyun Chen, Youtian Hu, Jun Hu, Weishan Yang, Jean-Marc Sabatier, Michel De Waard, Zhijian Cao, Wenxin Li, Song Han*, Yingliang Wu*, Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues. Biochem Biophys Res Commun. 2014, 447(1): 70-6. (Co-correspongding author)

6. Jinzhi Lu, Xiong Chen, Yingying Zhang, Jian Xu, Lianglu Zhang, Zhi Li, Wanhong Liu,Jingping Ouyang, Song Han*, Xiaohua He*, Astragalus polysaccharide inducesanti-inflammatory effects dependent on AMPK activity in palmitate-treated RAW264.7 cells. Int J Mol Med. 2013, 31(6):1463-70. (Co-correspongding author)

7. Jing Feng, Congya Yua, Mingyu Wang, Zhi Li, Yingliang Wu, Zhijian Cao, Wenxin Li , Xiaohua He, Song Han*, Expression and characterization of a novel scorpine-like peptide Ev37, from the scorpion Chaerilus tricostatus. Protein Expression and Purification. 2013, 88(1):127-33.